The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Sep. 05, 2014
University of Washington Through Its Center for Commercialization, Seattle, WA (US);
Michael H. Gelb, Seattle, WA (US);
Arun Babu Kumar, Seattle, WA (US);
Frances Hocutt, Seattle, WA (US);
Zdenek Spacil, Seattle, WA (US);
Mariana Natali Barcenas Rodriguez, Seattle, WA (US);
Frantisek Turecek, Seattle, WA (US);
C. Ronald Scott, Seattle, WA (US);
University of Washington through its Center for Commercialization, Seattle, WA (US);
Abstract
Reagents, methods, and kits for assaying enzymes associated with lysosomal storage diseases MPS-I, MPS-II, MPS-IIIA, MPS-IIIB, MPS-IV A, MPS-VI, and MPS VII. In one aspect, the invention provides methods for assaying one or more enzymes associated with a lysosomal storage disease. In a first embodiment, the method includes: (a) contacting a sample with a first solution to provide a solution comprising one or more lysosomal enzymes; (b) contacting the one or more lysosomal enzymes in solution with an enzyme substrate for each lysosomal enzyme to be analyzed and incubating the substrates with the enzymes for a time sufficient to provide a solution comprising an enzyme product for each lysosomal enzyme present in the sample.