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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10196613 B1

PDFFull Text
Date of Patent:
Feb. 05, 2019

Filed:

Dec. 18, 2015

Stem cells for modeling type 2 diabetes

Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Guochun Gong, Elmsford, NY (US);

Ka-Man Venus Lai, Tarrytown, NY (US);

David M. Valenzuela, Yorktown Heights, NY (US);

Assignee:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:

Yongjin Choi

Alston & Bird LLP

Primary Examiner:

Thaian N Ton

Assistant Examiner:

David A Montanari

Int. Cl.
CPC ...
C12N 5/074 (2010.01); A01K 67/027 (2006.01); C12N 5/071 (2010.01); G01N 33/50 (2006.01); G01N 33/74 (2006.01); A61K 35/39 (2015.01); A61K 35/545 (2015.01); C12N 15/10 (2006.01); C12N 15/90 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); A01K 67/0271 (2013.01); A61K 35/39 (2013.01); A61K 35/545 (2013.01); C12N 5/0676 (2013.01); C12N 5/0678 (2013.01); C12N 15/102 (2013.01); C12N 15/111 (2013.01); C12N 15/90 (2013.01); G01N 33/507 (2013.01); G01N 33/5088 (2013.01); G01N 33/74 (2013.01); A01K 2207/12 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0362 (2013.01); C12N 2310/20 (2017.05); C12N 2501/119 (2013.01); C12N 2501/16 (2013.01); C12N 2506/45 (2013.01); G01N 2333/62 (2013.01);
Abstract

The invention provides stem cell derived beta-pancreatic cells and animal models of T2D in which cells have been grafted. The stem cells bear a mutated form of SLC30A8 conferring protection or susceptibility to T2D. The cells and animal models can be used for drug screening as well as to provide insights into the mechanism of T2D and potentially new therapeutic and diagnostic targets.

Find Patent Forward Citations

Gong, Guochun. (2019). Stem cells for modeling type 2 diabetes (U.S. Patent No. 10196613). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10196613

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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