The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 05, 2019

Filed:

Aug. 17, 2017
Applicants:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);

Biomed Valley Discoveries, Inc., Kansas City, MO (US);

Inventors:

Dimiter Dimitrov, Frederick, MD (US);

Zhongyu Zhu, Frederick, MD (US);

Brad St. Croix, Frederick, MD (US);

Enrique Zudaire, Germantown, MD (US);

Saurabh Saha, Wellesley Hills, MA (US);

Xiaoyan Michelle Zhang, Lexington, MA (US);

Gary Decrescenzo, Parkville, MO (US);

Dean Welsch, Parkville, MO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); A61P 35/00 (2006.01); G01N 33/574 (2006.01); A61P 31/04 (2006.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 47/68 (2017.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61K 49/16 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 9/0019 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6855 (2017.08); A61K 47/6865 (2017.08); A61K 49/16 (2013.01); A61P 31/04 (2018.01); A61P 35/00 (2018.01); C07H 21/04 (2013.01); C07K 14/7051 (2013.01); C07K 16/30 (2013.01); C07K 16/3046 (2013.01); C12N 15/09 (2013.01); C12N 15/63 (2013.01); G01N 33/574 (2013.01); G01N 33/57419 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); C07K 2317/21 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.


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