The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Jul. 14, 2015
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Fajun Nan, Shanghai, CN;
Jia Li, Shanghai, CN;
Jingya Li, Shanghai, CN;
Mei Zhang, Shanghai, CN;
Dakai Chen, Shanghai, CN;
Lina Zhang, Shanghai, CN;
Runtao Zhang, Shanghai, CN;
Zhifu Xie, Shanghai, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Zhangjiang, Pudong, Shanghai, CN;
Abstract
Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.