The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Aug. 24, 2017
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Matthew B. Soellner, Dexter, MI (US);
Sameer Phadke, Mumbai, IN;
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 213/68 (2006.01); C07D 213/81 (2006.01); C07D 215/20 (2006.01); C07D 215/38 (2006.01); C07D 239/74 (2006.01); C07D 295/135 (2006.01); A61K 31/44 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 213/68 (2013.01); C07D 213/81 (2013.01); C07D 215/20 (2013.01); C07D 215/38 (2013.01); C07D 239/74 (2013.01); C07D 295/135 (2013.01);
Abstract
Inhibitor compounds of Bcr-Abl and Bcr-Abl mutants including Bcr-Abl T315I mutant protein are disclosed. Compositions comprising the inhibitor compounds and methods of using the compounds in the treatment of leukemia such as chronic myelogenous leukemia are also disclosed.