The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 05, 2019

Filed:

Aug. 15, 2014
Applicant:

Arromax Pharmatech Co., Ltd., Suzhou, Jiangsu, CN;

Inventors:

Jian Hong, Suzhou, CN;

Xin Xu, Suzhou, CN;

Xiaoyong Le, Suzhou, CN;

Zonghua Zhang, Suzhou, CN;

Assignee:

ARROMAX PHARMATECH CO., LTD., Suzhou, Jiangsu, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/94 (2006.01); A61K 31/517 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 239/94 (2013.01); A61K 31/517 (2013.01); C07D 401/12 (2013.01);
Abstract

Disclosed are a quinazoline derivative, a preparation method therefor, and a pharmaceutical composition and an application thereof. The present invention provides a compound represented by general formula I, a stereoisomer thereof and a pharmaceutical acceptable salt or a solvate thereof. The quinazoline derivative of the present invention has a unique chemical structure, is characterized by irreversibly inhibiting EGFR tyrosine kinase, has high biological activity, apparently improves the inhibiting effect on the EGFR tyrosine kinase, has quite strong tumor inhibiting effect on tumor cells and a transplantation tumor pathological model of animal tumors, and has good market developing prospects.


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Hong, Jian. (2019). Quinazoline derivative, preparation method therefor, and pharmaceutical composition and application thereof (U.S. Patent No. 10196365). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10196365

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