The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Aug. 03, 2015
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Justin Scot Hanes, Baltimore, MD (US);
Qing Pan, Hangzhou, CN;
Qingguo Xu, Baltimore, MD (US);
Nicholas J. Boylan, East Boston, MD (US);
Walter J. Stark, Baltimore, MD (US);
Bing Wang, Fujian Province, CN;
Lixia Luo, Guangdong Province, CN;
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/573 (2006.01); A61K 9/00 (2006.01); A61K 31/00 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 31/573 (2013.01); A61K 9/0048 (2013.01); A61K 9/0051 (2013.01); A61K 9/5031 (2013.01); A61K 9/5153 (2013.01); A61K 31/00 (2013.01);
Abstract
Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (DSP) into a matrix such as biodegradable poly(lactic-coglycolic acid) (PLGA) which is densely coated with hydrophilic polymer such as PEG or PLURONIC® F127, exhibit sustained release of DSP for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.