The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
May. 02, 2016
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Dong-Ming Shen, Edision, NJ (US);
Jonathan E. Wilson, Rahway, NJ (US);
Troy McCracken, Berkeley Heights, NJ (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); C07D 239/36 (2006.01); C07D 403/04 (2006.01); A61P 25/06 (2006.01); A61P 25/28 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/16 (2006.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A61P 25/06 (2018.01); A61P 25/16 (2018.01); A61P 25/18 (2018.01); A61P 25/22 (2018.01); A61P 25/28 (2018.01);
Abstract
The present invention is directed to substituted pyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.