The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2019
Filed:
Apr. 12, 2016
Applicant:
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Inventors:
Soumen Jana, Rochester, MN (US);
Amir Lerman, Rochester, MN (US);
Robert D. Simari, Mission Hills, KS (US);
Assignee:
Mayo Foundation for Medical Education and Research, Rochester, MN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 2/24 (2006.01); A61L 27/38 (2006.01); A61L 27/36 (2006.01);
U.S. Cl.
CPC ...
A61F 2/2415 (2013.01); A61L 27/367 (2013.01); A61L 27/3691 (2013.01); A61L 27/3804 (2013.01); A61L 27/3895 (2013.01); A61F 2/2412 (2013.01); A61F 2210/0076 (2013.01); A61F 2310/00365 (2013.01); A61F 2310/00371 (2013.01); A61L 2400/12 (2013.01); A61L 2430/20 (2013.01);
Abstract
Systems and methods for producing biologic tissues are described. For example, this document provides electrospinning systems and culturing techniques to make biologic heart valve leaflets and fibrosa layers of native valve leaflet having nanofibrous substrate layer(s). In some implementations, a tri-layered leaflet with circumferentially, randomly, and radially oriented nanofibers that mimics morphologies of native leaflets.