The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Jul. 08, 2014
Novartis Ag, Basel, CH;
Children's Medical Center Corporation, Boston, MA (US);
Brandeis University, Waltham, MA (US);
Philip R. Dormitzer, Cambridge, MA (US);
Nikolaus Grigorieff, Leesburg, VA (US);
Stephen Harrison, Boston, MA (US);
Junhua Pan, Brookline, MA (US);
Ethan Settembre, Cambridge, MA (US);
Novartis AG, Basel, CH;
Abstract
The present invention relates to the use of rotavirus particles for displaying a heterologous protein, alone or in complex with another molecule. The invention further relates to methods that employ these modified rotavirus particles to rapidly determine the structure of the heterologous protein or the complex using cryo-electron microscopy (cryo-EM). The invention also relates to a method of immunizing a patient, wherein said method comprises administering to the patient the modified rotavirus particles of the invention.