The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Oct. 07, 2016
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Assignee:
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/545 (2006.01); G01N 33/574 (2006.01); A61K 31/4545 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
C12N 9/12 (2013.01); A61K 31/4545 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/545 (2013.01); C12Q 1/6886 (2013.01); C12Y 207/10 (2013.01); G01N 33/57484 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/912 (2013.01); G01N 2500/10 (2013.01); G01N 2800/52 (2013.01);
Abstract
The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase ('TALK'). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.