The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Dec. 16, 2017
Wyeth Llc, Madison, NJ (US);
Edward Roland LaVallie, Harvard, MA (US);
Lisa Anne Collins-Racie, Acton, MA (US);
Christopher John Corcoran, Arlington, MA (US);
Lioudmila Gennadievna Tchistiakova, Andover, MA (US);
John Adam Nowak, Stratham, NH (US);
Riyez Karim, North Andover, MA (US);
Xiang-Yang Tan, Reading, MA (US);
Kimberly Ann Marquette, Somerville, MA (US);
Geertruida Machteld Veldman, Sudbury, MA (US);
PFIZER INC., New York, NY (US);
Abstract
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.