The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Nov. 11, 2016
Applicants:
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Zug, CH;
Inventors:
Falko-Günter Falkner, Orth/Donau, AT;
Franziska Horling, Gaenserndorf, AT;
Johannes Lengler, Vienna, AT;
Hanspeter Rottensteiner, Vienna, AT;
Friedrich Scheiflinger, Vienna, AT;
Assignees:
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta GmbH, Zug, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/755 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2750/14143 (2013.01); C12N 2840/007 (2013.01);
Abstract
The present disclosure provides, among other aspects, codon-altered polynucleotides encoding Factor VIII variants for expression in mammalian cells. In some embodiments, the disclosure also provides mammalian gene therapy vectors and methods for treating hemophilia A.