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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10189822 B1

PDFFull Text
Date of Patent:
Jan. 29, 2019

Filed:

Mar. 15, 2016

Heterocyclic modulators of lipid synthesis

Applicant:

3-v Biosciences, Inc., Menlo Park, CA (US);

Inventors:

Johan D. Oslob, Menlo Park, CA (US);

Robert S. McDowell, Menlo Park, CA (US);

Russell Johnson, Menlo Park, CA (US);

Hanbiao Yang, Menlo Park, CA (US);

Marc Evanchik, Menlo Park, CA (US);

Cristiana A. Zaharia, Menlo Park, CA (US);

Haiying Cai, Menlo Park, CA (US);

Lily W. Hu, Menlo Park, CA (US);

Gregory Duke, Menlo Park, CA (US);

Yamini Ohol-Gupta, Menlo Park, CA (US);

Timothy Sean Heuer, Menlo Park, CA (US);

Marie O'Farrell, Menlo Park, CA (US);

Assignee:

3-V Biosciences, Inc., Menlo Park, CA (US);

Attorney:

Cooley LLP

Primary Examiner:

Taofiq A Solola

Int. Cl.
CPC ...
C07D 405/12 (2006.01); C07D 401/12 (2006.01); C07D 407/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 211/34 (2006.01); A61K 31/451 (2006.01); A61K 31/4525 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 401/10 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/451 (2013.01); A61K 31/454 (2013.01); A61K 31/4525 (2013.01); A61K 31/4545 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 211/34 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 407/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.

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