The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 29, 2019

Filed:

Dec. 07, 2015
Applicants:

Merck Sharp & Dohme Corp.;

Mochida Pharmaceutical Co., Ltd, Tokyo, JP;

Inventors:

Ting Zhang, Princeton Junction, NJ (US);

Yi-Heng Chen, Whippany, NJ (US);

Liangqin Guo, Edison, NJ (US);

Alan Hruza, Hackettstown, NJ (US);

Tianying Jian, Westfield, NJ (US);

Bing Li, Towaco, NJ (US);

Dongfang Meng, Morganville, NJ (US);

Dann L. Parker, Cranford, NJ (US);

Edward C. Sherer, Manville, NJ (US);

Harold B. Wood, Westfield, NJ (US);

Isao Sakurada, Tokyo, JP;

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 413/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.


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