The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Apr. 08, 2016
Applicant:
Orion Corporation, Espoo, FI;
Inventors:
Ilpo Laitinen, Espoo, FI;
Oskari Karjalainen, Helsinki, FI;
Assignee:
Orion Corporation, Espoo, FI;
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/12 (2006.01); C07D 405/04 (2006.01); C07D 403/12 (2006.01); C07D 207/34 (2006.01); C07D 207/337 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); C07D 207/337 (2013.01); C07D 207/34 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01);
Abstract
The present invention relates to an improved process for the preparation of carboxamide structured androgen receptor (AR) antagonists such as N—((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide (1A) and key intermediates thereof such as 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile (V). AR antagonists are useful in the treatment of cancer, particularly prostate cancer and other diseases where AR antagonism is desired.