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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10189769 B1

PDFFull Text
Date of Patent:
Jan. 29, 2019

Filed:

Nov. 26, 2014

Method for preparation of pharmaceutically acceptable chlorogenic acid

Applicant:

Sichuan Jiuzhang Biological Science and Technology Co., Ltd, Chengdu, Sichuan, CN;

Inventors:

Jie Zhang, Sichuan, CN;

Liang Zhang, Sichuan, CN;

Wang Huang, Sichuan, CN;

Assignee:

SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD., Chengdu, Sichuan, CN;

Attorneys:

Novick, Kim & Lee, PLLC

Allen Xue

Primary Examiner:

Pancham Bakshi

Assistant Examiner:

Mark R Luderer

Int. Cl.
CPC ...
B01D 9/00 (2006.01); B01D 9/04 (2006.01); C07C 35/14 (2006.01); C07C 39/10 (2006.01); C07C 67/48 (2006.01); C07C 67/52 (2006.01); C07C 67/56 (2006.01); A61K 31/216 (2006.01); C07C 69/732 (2006.01);
U.S. Cl.
CPC ...
C07C 67/52 (2013.01); A61K 31/216 (2013.01); B01D 9/0022 (2013.01); B01D 9/04 (2013.01); C07C 35/14 (2013.01); C07C 39/10 (2013.01); C07C 67/48 (2013.01); C07C 67/56 (2013.01); C07C 69/732 (2013.01); B01D 2009/0086 (2013.01);
Abstract

The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.

Find Patent Forward Citations

Zhang, Jie. (2019). Method for preparation of pharmaceutically acceptable chlorogenic acid (U.S. Patent No. 10189769). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10189769

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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