The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
May. 11, 2017
Applicant:
Glaxosmithkline Biologicals SA, Rixensart, BE;
Inventor:
Francesco Berti, Siena, IT;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/09 (2006.01); C07K 14/315 (2006.01); A61K 39/385 (2006.01); A61K 47/64 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/092 (2013.01); A61K 39/09 (2013.01); A61K 39/385 (2013.01); A61K 47/643 (2017.08); A61K 47/646 (2017.08); A61K 47/6415 (2017.08); C07K 14/315 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6031 (2013.01); A61K 2039/6037 (2013.01); A61K 2039/6068 (2013.01); A61K 2039/6081 (2013.01); A61K 2039/627 (2013.01); A61K 2039/64 (2013.01);
Abstract
Three conjugation methods for use with the capsular saccharide of. In the first method, reductive amination of oxidized sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method, sialic acid residues and/or N-acetyl-glucosamine residues are de-N-acetylated to give amine groups, and the amine groups are coupled to a carrier protein via a linker. In the third method, linkage is via galactose residues in the capsular saccharide rather than sialic acid residues, which can conveniently be achieved using galactose oxidase.