The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
May. 05, 2017
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Ha-Soon Choi, San Diego, CA (US);
James Paul Lajiness, San Diego, CA (US);
Srinivasa Reddy Natala, San Diego, CA (US);
Bao Nguyen, San Diego, CA (US);
Hank Michael James Petrassi, San Diego, CA (US);
Zhicheng Wang, San Diego, CA (US);
Assignee:
Novartis AG, Basel, CH;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/443 (2006.01); C07D 493/08 (2006.01); A61K 31/4245 (2006.01); A61K 31/4155 (2006.01); A61K 31/506 (2006.01); A61K 31/34 (2006.01); A61K 31/4439 (2006.01); A61K 31/5377 (2006.01); A61K 31/351 (2006.01); A61K 31/4545 (2006.01); A61K 31/4525 (2006.01); A61K 31/497 (2006.01); A61K 31/444 (2006.01); A61K 45/06 (2006.01); C07D 491/18 (2006.01); A61K 31/416 (2006.01); A61K 31/4433 (2006.01); A61L 27/54 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
A61K 31/443 (2013.01); A61K 31/34 (2013.01); A61K 31/351 (2013.01); A61K 31/416 (2013.01); A61K 31/4155 (2013.01); A61K 31/4245 (2013.01); A61K 31/444 (2013.01); A61K 31/4433 (2013.01); A61K 31/4439 (2013.01); A61K 31/4525 (2013.01); A61K 31/4545 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61L 27/54 (2013.01); C07D 491/18 (2013.01); C07D 493/08 (2013.01); C12N 5/0655 (2013.01); A61L 2300/412 (2013.01); A61L 2430/06 (2013.01); C12N 2501/999 (2013.01); C12N 2506/1346 (2013.01);
Abstract
The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.