The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Feb. 29, 2016
Applicant:
Case Western Reserve University, Cleveland, OH (US);
Inventor:
James Basilion, Shaker Heights, OH (US);
Assignee:
Case Western Reserve University, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 18/20 (2006.01); A61N 5/10 (2006.01); A61B 34/10 (2016.01); A61B 10/00 (2006.01); A61B 10/02 (2006.01); A61K 49/00 (2006.01); A61B 18/00 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0071 (2013.01); A61B 5/0091 (2013.01); A61B 5/4064 (2013.01); A61B 5/4381 (2013.01); A61B 5/444 (2013.01); A61B 5/4836 (2013.01); A61B 5/7264 (2013.01); A61B 10/0041 (2013.01); A61B 10/02 (2013.01); A61B 18/20 (2013.01); A61B 34/10 (2016.02); A61K 49/0032 (2013.01); A61K 49/0052 (2013.01); A61N 5/1039 (2013.01); A61N 5/1084 (2013.01); A61B 2018/00577 (2013.01); A61B 2034/104 (2016.02); A61B 2576/00 (2013.01);
Abstract
A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, an applicator for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell.