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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10184933 B1

PDFFull Text
Date of Patent:
Jan. 22, 2019

Filed:

Oct. 01, 2014

Compositions, systems and methods for gene expression noise drug screening and uses thereof

Applicant:

The J. David Gladstone Institutes, San Francisco, CA (US);

Inventors:

Leor Weinberger, Oakland, CA (US);

Roy Dar, Champaign, IL (US);

Assignee:

The J. David Gladstone Industries, San Francisco, CA (US);

Attorneys:

Taylor English Duma LLP

Siegfried J. W. Ruppert

Primary Examiner:

James S Ketter

Int. Cl.
CPC ...
C12Q 1/68 (2018.01); G01N 33/50 (2006.01); C12Q 1/6897 (2018.01); C12Q 1/70 (2006.01); A61K 31/22 (2006.01); A61K 31/496 (2006.01); A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5023 (2013.01); A61K 31/22 (2013.01); A61K 31/496 (2013.01); A61K 38/191 (2013.01); C12Q 1/6897 (2013.01); C12Q 1/703 (2013.01); G01N 2333/16 (2013.01);
Abstract

HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency.

Find Patent Forward Citations

Weinberger, Leor. (2019). Compositions, systems and methods for gene expression noise drug screening and uses thereof (U.S. Patent No. 10184933). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10184933

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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