The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Jun. 19, 2015
Applicant:
Aptalis Pharma Ltd., Wicklow, IE;
Inventors:
Giovanni Ortenzi, Monza, IT;
Luigi Ghidorsi, Milan, IT;
Assignee:
ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED, Dublin, IE;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/94 (2006.01); C12Q 1/6806 (2018.01); A61K 38/46 (2006.01); A61K 38/47 (2006.01); A61K 38/48 (2006.01); C12Q 1/70 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/94 (2013.01); A61K 38/465 (2013.01); A61K 38/47 (2013.01); A61K 38/482 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/707 (2013.01); A61K 38/00 (2013.01); C12Y 301/00 (2013.01); C12Y 302/01 (2013.01); C12Y 304/21 (2013.01);
Abstract
Methods for screening pancrelipase for RNA virus contamination comprise removing free viral RNA from the pancrelipase, denaturing any viruses in the pancrelipase to release encapsidated RNA into the pancrelipase milieu, and detecting this released RNA. Removal of free viral RNA may comprise treating pancrelipase with RNase and DNase or precipitating the protein fraction of pancrelipase with a salt that precipitates the protein fraction while leaving nucleic acids such as RNA in solution. Pancrelipase substantially devoid of free nucleic acid is also provided.