The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Jun. 07, 2016
Abbvie Inc., North Chicago, IL (US);
Mark Anderson, Grayslake, IL (US);
Jieyi Wang, Belmont, CA (US);
Archana Thakur, Pleasanton, CA (US);
Debra Chao, Fremont, CA (US);
Chung-Ming Hsieh, Newton, MA (US);
Qian Zhang, Gurnee, IL (US);
Edward B. Reilly, Libertyville, IL (US);
Enrico L. Digiammarino, Lindenhurst, IL (US);
Kenton L. Longenecker, Grayslake, IL (US);
Russell A. Judge, Gurnee, IL (US);
David A. Egan, Gurnee, IL (US);
Charles W. Hutchins, Green Oaks, IL (US);
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).