The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Mar. 14, 2014
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Zug, CH;
Ruth Madlener, Vienna, AT;
Wolfgang Teschner, Vienna, AT;
Hans-Peter Schwarz, Vienna, AT;
Sonja Svatos, Berg, AT;
Azra Pljevljakovic, Vienna, AT;
Lena Nitsch, Vienna, AT;
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta GmbH, Zug, CH;
Abstract
The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.