The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Oct. 26, 2012
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Colleen Barr, Pennsburg, PA (US);
Akhilesh Bhambhani, Doylestown, PA (US);
Robert Evans, Souderton, PA (US);
Lynne Isopi, Sellersville, PA (US);
David Krah, Lansdale, PA (US);
Jennifer Kriss, Blue Bell, PA (US);
Jessica Sinacola, Collegeville, PA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Methods for preparing lyophilized pellets of biological materials are described. The pellets have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a flat, solid surface, in particular, a surface that does not have any cavities, followed by lyophilizing the frozen droplets. These methods are useful for preparing lyophilized pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.