The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Aug. 31, 2015
Applicant:
Katholieke Universiteit Leuven, Leuven, BE;
Inventors:
Assignee:
KATHOLIEKE UNIVERSITEIT LEUVEN, Leuven, BE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 19/16 (2006.01); C07H 19/167 (2006.01); C12N 9/10 (2006.01); C12Q 1/6876 (2018.01);
U.S. Cl.
CPC ...
C07H 19/16 (2013.01); C07H 19/167 (2013.01); C12N 9/1007 (2013.01); C12Q 1/6876 (2013.01); C12Y 201/01072 (2013.01); C12Q 2600/154 (2013.01);
Abstract
Cofactor analogs for methyltransferases are disclosed. The compounds are represented by formula (I) wherein R1 is COOH or COO—; X is an organic or inorganic anion carrying one or more negative charges; Y and Y' are H, or an alkyl; R2 is NH, NHBoc, or H; and Z is S or Se. R comprises a carbon-carbon double bond, carbon-oxygen double bond, carbon-sulfur double bond, carbon-nitrogen double bond, a carbon-carbon triple bond, carbon-nitrogen triple bond, an aromatic carbocyclic or heterocyclic system in β-position to the sulfonium center, unsaturated c-c bond, or c-heteroatom bond where the heteroatom is O, N, S.