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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10183953 B1

PDFFull Text
Date of Patent:
Jan. 22, 2019

Filed:

Apr. 04, 2017

Substituted 2-azabicycles and their use as orexin receptor modulators

Applicant:

Janssen Pharmaceutica NV, Beerse, BE;

Inventors:

Christine F. Gelin, San Diego, CA (US);

Terry P. Lebold, San Diego, CA (US);

Brock T. Shireman, Poway, CA (US);

Jeannie M. Ziff, San Diego, CA (US);

Assignee:

Janssen Pharmaceutica NV, Beerse, BE;

Attorney:

Thomas J. Dodd

Primary Examiner:

Alexander R Pagano

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
C07D 471/08 (2006.01); C07D 519/00 (2006.01); C07D 513/04 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 487/08 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/497 (2006.01); A61K 31/506 (2006.01); C07D 405/14 (2006.01); C07D 417/14 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
C07D 513/04 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61P 25/00 (2018.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); C07D 487/08 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention is directed to compounds of Formula I: wherein X is N or CR; Y is N or CR; Ris H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl; Ris H, alkyl, alkoxy, or halo; Z is NH or O; Ris H, alkyl, alkoxy, halo, or triazolyl; Ris H or alkyl; or Rand R, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring; Ris pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl; and n is 1 or 2. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.

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