The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 22, 2019

Filed:

Feb. 05, 2016
Applicant:

Sunshine Lake Pharma Co., Ltd., Dongguan, Guangdong, CN;

Inventors:

Xiaojun Wang, Dongguan, CN;

Xinye Yang, Dongguan, CN;

Shengqiang Pan, Dongguan, CN;

Rui Guo, Dongguan, CN;

Junwen Wu, Dongguan, CN;

Yingjun Zhang, Dongguan, CN;

Changchung Cheng, Guangdong, CN;

Assignee:

SUNSHINE LAKE PHARMA CO., LTD., Dongguan, Guangdong, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 261/08 (2006.01); C07D 249/06 (2006.01); A61K 31/42 (2006.01); A61K 31/4353 (2006.01); A61K 31/4985 (2006.01); A61K 31/519 (2006.01); C07D 411/12 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 491/044 (2006.01); C07D 497/04 (2006.01); C07D 498/14 (2006.01); C07D 491/052 (2006.01); C07D 491/147 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 261/08 (2013.01); A61K 31/42 (2013.01); A61K 31/4353 (2013.01); A61K 31/4985 (2013.01); A61K 31/519 (2013.01); C07D 249/06 (2013.01); C07D 411/12 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 491/044 (2013.01); C07D 491/052 (2013.01); C07D 491/147 (2013.01); C07D 497/04 (2013.01); C07D 498/04 (2013.01); C07D 498/14 (2013.01);
Abstract

The present invention relates to novel tricyclic compounds which can bind to FXR and act as modulators of the FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the uses of the compounds for the treatment of diseases and/or conditions mediated by FXR. The invention further provides a pharmaceutical composition containing the compound disclosed herein and a method of treatment of diseases and/or conditions mediated by FXR comprising administering the compound or the pharmaceutical composition.


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