The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Sep. 09, 2016
Chiral Quest (Suzhou) Co., Ltd., Jiangsu, CN;
Jiangxi Long Life Bio-pharmaceutical Co., Ltd., Jiangxi, CN;
Shengwen Wu, Jiangsu, CN;
Wenge Li, Jiangsu, CN;
Lei Wu, Jiangsu, CN;
Li Zou, Jiangsu, CN;
Siming Hu, Jiangsu, CN;
Tengyue Xu, Jiangsu, CN;
Hongfeng Liu, Jiangsu, CN;
Yi Tao, Jiangsu, CN;
Yongxiang Chi, Jiangsu, CN;
CHIRAL QUEST (SUZHOU) CO., LTD., Jiangsu, CN;
JIANGXI LONG LIFE BIO-PHARMACEUTICAL CO., LTD., Jiangxi, CN;
Abstract
A process is provided for preparation of (R)-N-Boc biphenyl alaninol. It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 in the presence of [Rh(Duanphos)(X)]Y and hydrogen to provide compound 4. Here 'Duanphos' is (Rc,Sp)-Duanphos or (Sc,Rp)-Duanphos; X is NBD or/and COD; Y is one or more of BF4, PF6, SbF6. This process has a lot of advantages, such as low cost, safe operation, less pollution and high yield. The product was obtained in >99% purity and ee which is suitable to scale up in industrial scale.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile