The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Sep. 01, 2017
Applicant:
The Government of the United States of America, As Represented BY the Secretary of the Navy, Washington, DC (US);
Inventors:
Igor L. Medintz, Springfield, VA (US);
James B. Delehanty, Washington, DC (US);
Joyce Breger, Greenbelt, MD (US);
Markus Muttenthaler, Brisbane, AU;
Philip E. Dawson, San Diego, CA (US);
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01); A61K 47/64 (2017.01); A61K 47/69 (2017.01); A61K 31/704 (2006.01); A61K 47/52 (2017.01); A61K 47/62 (2017.01);
U.S. Cl.
CPC ...
A61K 47/641 (2017.08); A61K 31/704 (2013.01); A61K 38/08 (2013.01); A61K 47/52 (2017.08); A61K 47/62 (2017.08); A61K 47/645 (2017.08); A61K 47/6923 (2017.08); A61K 47/6929 (2017.08);
Abstract
Nanoparticles (and optionally a cargo such as a drug) can be delivered to cells by attaching just a single dendritic peptide to the nanoparticle. The dendritic peptide includes a polyhisitidine motif and a hinge and a spacer connecting the polyhistidine to a lysine-based dendritic wedge displaying at least two copies of a cell-penetrating peptide motif.