The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2019
Filed:
Apr. 08, 2016
The Secretary, Department of Atomic Energy, Mumbai, IN;
Deepak Sharma, Mumbai, IN;
Santosh Kumar Sandur, Mumbai, IN;
Rahul Checker, Mumbai, IN;
Raghavendra Shridhar Patwardhan, Mumbai, IN;
Vikram Prakash Gota, Mumbai, IN;
Jayakumar Sundarraj, Mumbai, IN;
Preetha Sasi, Mumbai, IN;
Subrata Chattopadhyay, Mumbai, IN;
THE SECRETARY, DEPARTMENT OF ATOMIC ENERGY, Mumbai, IN;
Abstract
A method of increasing abundance of hematopoietic stem cells and progenitor cells and an adjuvant method of radiotherapy based treatment for radioprotection of the subject against γ-radiation toxicity and/or IR-induced death of cancer cells involving pharmaceutically effective dosages of chlorophyllin or a pharmaceutically acceptable salt thereof. The advancement is directed to selectively protect normal hematopoietic stem cells and/or sensitizes radio-resistant cancer cells to gamma radiation thereby lowering the risk of normal tissue radiation toxicity. The effective dose of the CHL formulation synergistically improves the outcome of radiotherapy for cancer when administered to the subject prior the radiotherapy for treating cancer. Also disclosed is kit having chlorophyllin containing therapeutic preparation for treating indications selected from reduction in hematopoietic stem cells and progenitor cells (HSPCs) and/or protection against whole body irradiation induced mortality.