IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10183021 B1

PDFFull Text
Date of Patent:
Jan. 22, 2019

Filed:

Aug. 24, 2016

Sgc stimulators

Applicant:

Ironwood Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Takashi Nakai, Newton, MA (US);

James Jia, Belmont, MA (US);

Paul Allan Renhowe, Sudbury, MA (US);

Timothy Claude Barden, Salem, MA (US);

Xiang Y. Yu, Acton, MA (US);

James Edward Sheppeck, Newton, PA (US);

Karthik Iyer, Cambridge, MA (US);

Joon Jung, Newton, MA (US);

George Todd Milne, Brookline, MA (US);

Kimberly Kafadar Long, Boston, MA (US);

Mark G. Currie, Boston, MA (US);

Joel Moore, Lexington, MA (US);

Nicholas Robert Perl, Somerville, MA (US);

Rajesh R. Iyengar, West Newton, MA (US);

Ara Mermerian, Waltham, MA (US);

G-Yoon Jamie Im, Cambridge, MA (US);

Thomas Wai-Ho Lee, Lexington, MA (US);

Colleen Hudson, Denver, CO (US);

Glen Robert Rennie, Somerville, MA (US);

Assignee:

Ironwood Pharmaceuticals, Inc., Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Steven G. Davis

Xin Zhang

Primary Examiner:

Anna Pagonakis

Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01); C07D 413/14 (2006.01); C07D 403/04 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); A61K 31/519 (2006.01); A61K 31/55 (2006.01); C07D 401/14 (2006.01); C07D 471/08 (2006.01); C07D 471/10 (2006.01); A61K 45/06 (2006.01); C07D 451/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 451/02 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 495/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

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