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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10183007 B1

PDFFull Text
Date of Patent:
Jan. 22, 2019

Filed:

Dec. 21, 2015

Method of producing proanthocyanidin oligomer

Applicants:

Nagasaki University, Nagasaki, JP;

Usaien Pharmaceutical Co., Ltd., Saga, JP;

Amino Up Chemical Co., Ltd., Hokkaido, JP;

Inventors:

Takashi Tanaka, Nagasaki, JP;

Gen-ichiro Nonaka, Saga, JP;

Isao Kohno, Nagasaki, JP;

Hajime Fujii, Hokkaido, JP;

Takashi Nakagawa, Hokkaido, JP;

Hiroshi Nishioka, Hokkaido, JP;

Assignees:

Usien Pharmaceutical Co., Ltd., Saga-Shi, Saga, JP;

Amino Up Chemical Co., Ltd., Sapporo-Shi, Hokkaido, JP;

Nagasaki University, Nagasaki, JP;

Attorney:

Allen Dyer Doppelt & Gilchrist

Primary Examiner:

Qiuwen Mi

Int. Cl.
CPC ...
A61K 36/00 (2006.01); A61K 31/353 (2006.01); A61K 8/49 (2006.01); A61K 36/04 (2006.01); A61K 36/14 (2006.01); A61K 36/15 (2006.01); A61K 36/185 (2006.01); A61K 36/485 (2006.01); A61K 36/54 (2006.01); A61K 36/61 (2006.01); A61K 36/73 (2006.01); A61K 36/734 (2006.01); A61K 36/74 (2006.01); A61K 36/77 (2006.01); A61K 36/82 (2006.01); A61K 36/87 (2006.01); A61K 36/88 (2006.01); A61K 36/889 (2006.01); A61Q 19/08 (2006.01); C07D 311/62 (2006.01); A61K 36/45 (2006.01);
U.S. Cl.
CPC ...
A61K 31/353 (2013.01); A61K 8/498 (2013.01); A61K 36/04 (2013.01); A61K 36/14 (2013.01); A61K 36/15 (2013.01); A61K 36/185 (2013.01); A61K 36/45 (2013.01); A61K 36/485 (2013.01); A61K 36/54 (2013.01); A61K 36/61 (2013.01); A61K 36/73 (2013.01); A61K 36/734 (2013.01); A61K 36/74 (2013.01); A61K 36/77 (2013.01); A61K 36/82 (2013.01); A61K 36/87 (2013.01); A61K 36/88 (2013.01); A61K 36/889 (2013.01); A61Q 19/08 (2013.01); C07D 311/62 (2013.01); A61K 2800/522 (2013.01);
Abstract

The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.

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