The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 15, 2019

Filed:

Aug. 21, 2017
Applicant:

National Technology & Engineering Solutions of Sandia, Llc, Albuquerque, NM (US);

Inventor:

Michael B. Sinclair, Albuquerque, NM (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 21/64 (2006.01); G01N 15/14 (2006.01); B01L 3/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 21/6428 (2013.01); B01L 3/502761 (2013.01); G01N 15/147 (2013.01); G01N 15/1427 (2013.01); G01N 15/1436 (2013.01); G01N 15/1459 (2013.01); G01N 15/1484 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0673 (2013.01); B01L 2300/0627 (2013.01); B01L 2400/0424 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/144 (2013.01); G01N 2015/149 (2013.01); G01N 2021/6439 (2013.01);
Abstract

A hyperspectral imaging flow cytometer can acquire high-resolution hyperspectral images of particles, such as biological cells, flowing through a microfluidic system. A trajectory-based triggering system can be used that will only trigger the acquisition of a hyperspectral image when an appropriate particle or cell is crossing an imaging line, thereby saving valuable resources and time. The hyperspectral imaging flow cytometer can provide detailed spatial maps of multiple emitting species, cell morphology information, and state of health. An optimized system can image about 20 cells per second. The hyperspectral imaging flow cytometer enables many thousands of cells to be characterized in a single session.


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