The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2019
Filed:
Sep. 04, 2014
Applicants:
The Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Emmanuelle Meuillet, Tucson, AZ (US);
Sylvestor Moses, Tucson, AZ (US);
Shuxing Zhang, Houston, TX (US);
Assignee:
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, Tucson, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61K 31/4164 (2006.01); A61K 31/4196 (2006.01); A61K 31/42 (2006.01); A61K 31/635 (2006.01); A61K 31/433 (2006.01); A61K 31/496 (2006.01); A61K 31/63 (2006.01); A61K 31/4439 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/635 (2013.01); A61K 31/4196 (2013.01); A61K 31/433 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/519 (2013.01); A61K 31/63 (2013.01); G01N 33/57434 (2013.01); A61K 31/4164 (2013.01); A61K 31/42 (2013.01); G01N 2333/47 (2013.01);
Abstract
T-lymphocyte invasion and metastases (Tiam-1) has been identified as a marker and anti-cancer drug target for therapy of metastatic bone cancer in individuals afflicted with prostate cancer. The present disclosure provides methods and compounds for inhibiting metastases by disrupting Tiam-1 expression and activity. One particularly preferred compound comprises a disulfomanide of the formula.