The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2019
Filed:
Dec. 16, 2013
The Regents of the University of California, Oakland, CA (US);
Yunfeng LU, Culver City, CA (US);
Ming Yan, Los Angeles, CA (US);
Irvin S. Y. Chen, Palos Verdes Estates, CA (US);
Min Liang, Los Angeles, CA (US);
Yunfeng Lu, Culver City, CA (US);
Ming Yan, Los Angeles, CA (US);
Irvin S. Y. Chen, Palos Verdes Estates, CA (US);
Min Liang, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo, and an ability to infect dividing and non-dividing cells with high efficiencies.