The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2019
Filed:
Jun. 11, 2012
Gabriela Venturini Da Silva, São Paulo, BR;
Alexandre Da Costa Pereira, São Paulo, BR;
José Eduardo Krieger, São Paulo, BR;
Deborah Schechtman, São Paulo, BR;
Pedro Lemos, São Paulo, BR;
Jeane Mike Tsutsui, São Paulo, BR;
Valdemir Melechco Carvalho, São Paulo, BR;
Karina Helena Morais Cardozo, São Paulo, BR;
Gabriela Venturini Da Silva, São Paulo, BR;
Alexandre Da Costa Pereira, São Paulo, BR;
José Eduardo Krieger, São Paulo, BR;
Deborah Schechtman, São Paulo, BR;
Pedro Lemos, São Paulo, BR;
Jeane Mike Tsutsui, São Paulo, BR;
Valdemir Melechco Carvalho, São Paulo, BR;
Karina Helena Morais Cardozo, São Paulo, BR;
Other;
Abstract
The present invention relates to the identification of a novel biomarker for cardiac ischemia: nitrated cardiac troponin I. The present invention also provides methods for the identification and use of a nitrated cardiac troponin as a biomarker for the diagnosis, prognosis and treatment management of myocardial ischemia, with and without necrosis of heart muscle. Diagnosis and prognosis is conducted by determining the amount of nitrated cardiac troponin I in serum samples of subjects and the ratio of nitrated cardiac troponin I to non-nitrated cardiac troponin I in serum samples of subjects. This biomarker can be detected by immunoassay techniques and tandem mass spectrometry. The present invention further relates to peptides, antibodies, compositions, methods, techniques, tests and kits for the identification and quantification of nitrated cardiac troponin I in samples of subjects.