The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2019
Filed:
Dec. 11, 2013
GE Healthcare Bio-sciences Corp., Marlborough, MA (US);
Arunkumar Natarajan, Niskayuna, NY (US);
Robert John Filkins, Niskayuna, NY (US);
Anup Sood, Niskayuna, NY (US);
Lakshmi Sireesha Kaanumalle, Niskayuna, NY (US);
Kashan Ali Shaikh, Niskayuna, NY (US);
Christina Lowes, Niskayuna, NY (US);
GE HEALTHCARE BIO-SCIENCES CORP., Marlborough, MA (US);
Abstract
Methods comprising the use of photoactivated chemical bleaching for detecting multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample including multiple targets, binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The method further includes the steps of contacting the sample comprising the bound probe with an electron transfer reagent, as well as an optional additive which prevents target modification during photoactivated chemical bleaching, and irradiating the sample, thereby initiating a photoreaction that substantially inactivates the probe by photoactivated chemical bleaching. The method further includes the steps of binding at least one probe to one or more target present in the sample, and detecting a signal from the probe. The process of binding, defecting and bleaching may be iteratively repeated.