The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 08, 2019

Filed:

Dec. 14, 2015
Applicant:

Hadasit Medical Research Services & Development Limited, Jerusalem, IL;

Inventors:

Sharona Cohen Evenram, Jerusalem, IL;

Benjamin Reubinoff, Moshav Bar-Giora, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0797 (2010.01); C12N 5/0793 (2010.01); A61K 35/30 (2015.01); C12N 5/00 (2006.01); A61K 31/337 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C12N 5/0623 (2013.01); A61K 35/30 (2013.01); C12N 5/0081 (2013.01); C12N 5/0619 (2013.01); A61K 31/337 (2013.01); A61K 39/39558 (2013.01); A61K 47/6855 (2017.08); A61K 47/6867 (2017.08); C12N 2501/06 (2013.01); C12N 2501/115 (2013.01); C12N 2501/119 (2013.01); C12N 2501/13 (2013.01); C12N 2501/15 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01);
Abstract

Provided is a method including providing a population of cells including a target type of differentiated cells having a pre-identified cytoskeletal profile and at least one cell selected from undifferentiated cells, differentiating cells and differentiated cells being different from the target type of differentiated cells; and incubating the population of cells with a cytotoxic agent, in an amount and for a time period effective to form a modified population of cells including predominantly or consisting essentially of the target type of differentiated cells. The pre-identified cytoskeletal profile can include the presence of class III β-tubulin on neuronal cells and the population of cells includes neural cells and neuronal cells.


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