The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 08, 2019

Filed:

Jun. 07, 2016
Applicant:

Emd Millipore Corporation, Burlington, MA (US);

Inventors:

Paul Ju-Sung Hung, Fremont, CA (US);

Philip Janmin Lee, Alameda, CA (US);

Assignee:

EMD Millipore Corporation, Burlington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/32 (2006.01); B01L 3/00 (2006.01); C12M 3/06 (2006.01); C12M 1/00 (2006.01); C12M 1/34 (2006.01); C12M 1/36 (2006.01); F16K 99/00 (2006.01); B29C 65/00 (2006.01); G01N 33/543 (2006.01); F16K 27/02 (2006.01); C12Q 1/02 (2006.01); G01N 33/50 (2006.01); G01N 35/00 (2006.01);
U.S. Cl.
CPC ...
C12M 23/12 (2013.01); B01L 3/50273 (2013.01); B01L 3/502707 (2013.01); B01L 3/502715 (2013.01); B01L 3/502738 (2013.01); B01L 3/502746 (2013.01); B29C 65/002 (2013.01); C12M 23/16 (2013.01); C12M 29/10 (2013.01); C12M 29/14 (2013.01); C12M 41/00 (2013.01); C12M 41/48 (2013.01); C12Q 1/025 (2013.01); F16K 27/0236 (2013.01); F16K 99/0001 (2013.01); F16K 99/0015 (2013.01); F16K 99/0059 (2013.01); G01N 33/5008 (2013.01); G01N 33/54366 (2013.01); B01L 3/5025 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/10 (2013.01); B01L 2300/123 (2013.01); B01L 2300/14 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0655 (2013.01); F16K 2099/0074 (2013.01); F16K 2099/0078 (2013.01); F16K 2099/0084 (2013.01); G01N 2035/00158 (2013.01); Y10T 137/2202 (2015.04);
Abstract

A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.


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