The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 08, 2019

Filed:

Aug. 14, 2017
Applicant:

Aquinox Pharmaceuticals (Canada) Inc., Vancouver, CA;

Inventors:

Lloyd F. Mackenzie, North Vancouver, CA;

Thomas B. MacRury, Point Roberts, WA (US);

Curtis Harwig, Vancouver, CA;

David Bogucki, Surrey, CA;

Jeffery R. Raymond, Vancouver, CA;

Jeremy D. Pettigrew, Burnaby, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 493/10 (2006.01); A61K 31/416 (2006.01); C07D 213/75 (2006.01); C07D 213/82 (2006.01); C07D 215/227 (2006.01); C07C 275/22 (2006.01); C07D 221/18 (2006.01); C07D 231/54 (2006.01); C07C 215/26 (2006.01); C07C 215/38 (2006.01); C07C 335/10 (2006.01); C07C 233/23 (2006.01); C07D 261/20 (2006.01); C07D 277/24 (2006.01); C07D 277/28 (2006.01); C07C 255/30 (2006.01); C07D 211/58 (2006.01); C07D 213/30 (2006.01); C07D 307/42 (2006.01); C07D 333/16 (2006.01); C07D 231/56 (2006.01); C07D 277/64 (2006.01); C07C 35/21 (2006.01); C07C 35/23 (2006.01); C07D 213/38 (2006.01); C07D 221/16 (2006.01); C07D 307/52 (2006.01); C07D 333/20 (2006.01);
U.S. Cl.
CPC ...
C07D 493/10 (2013.01); A61K 31/416 (2013.01); C07C 35/21 (2013.01); C07C 35/23 (2013.01); C07C 215/26 (2013.01); C07C 215/38 (2013.01); C07C 233/23 (2013.01); C07C 255/30 (2013.01); C07C 275/22 (2013.01); C07C 335/10 (2013.01); C07D 211/58 (2013.01); C07D 213/30 (2013.01); C07D 213/38 (2013.01); C07D 213/75 (2013.01); C07D 213/82 (2013.01); C07D 215/227 (2013.01); C07D 221/16 (2013.01); C07D 221/18 (2013.01); C07D 231/54 (2013.01); C07D 231/56 (2013.01); C07D 261/20 (2013.01); C07D 277/24 (2013.01); C07D 277/28 (2013.01); C07D 277/64 (2013.01); C07D 307/42 (2013.01); C07D 307/52 (2013.01); C07D 333/16 (2013.01); C07D 333/20 (2013.01); C07C 2601/14 (2017.05); C07C 2602/24 (2017.05);
Abstract

Compounds of formula (II): wherein R, R, Rand Rare described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.


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