The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2019
Filed:
May. 31, 2016
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Msd R & D (China) Co., Ltd., Shanghai, CN;
Dong-Ming Shen, Edison, NJ (US);
Michael P. Dwyer, Scotch Plains, NJ (US);
Christopher J. Sinz, South San Francisco, CA (US);
Deping Wang, Furlong, PA (US);
Shawn J. Stachel, Perkasie, PA (US);
Daniel V. Paone, Lansdale, PA (US);
Ashley Forster, Harleysville, PA (US);
Richard Berger, Harleysville, PA (US);
Yili Chen, Hillsborough, NJ (US);
Yimin Qian, Plainsboro, NJ (US);
Shimin Xu, Beijing, CN;
Chunmei Hu, Beijing, CN;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.