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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10174006 B1

PDFFull Text
Date of Patent:
Jan. 08, 2019

Filed:

May. 30, 2014

Topical aqueous ophthalmic compositions containing a 1h-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease

Applicant:

Novartis Ag, Basel, CH;

Inventors:

Malay Ghosh, Fort Worth, TX (US);

Christopher Michael Adams, Somerville, MA (US);

Stephanie Kay Dodd, Ayer, MA (US);

Stephen Hedrick Poor, Winthrop, MA (US);

Assignee:

NOVARTIS AG, Basel, CH;

Attorney:

Asha K. Nadipuram

Primary Examiner:

Ganapathy Krishnan

Int. Cl.
CPC ...
A61K 31/55 (2006.01); A61K 31/519 (2006.01); A61K 31/506 (2006.01); A61K 31/4439 (2006.01); A61K 31/724 (2006.01); C07D 403/12 (2006.01); C07D 401/12 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/04 (2006.01); C07D 519/00 (2006.01); A61K 9/00 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2017.01); A61K 9/08 (2006.01); A61K 47/38 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); A61K 9/0048 (2013.01); A61K 9/08 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/55 (2013.01); A61K 31/724 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/186 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01); C07D 401/12 (2013.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention is directed to the provision of a multi-dose topical ophthalmic composition containing a 1H-indole-1-carboxamide and use thereof for treatment of ophthalmic disease. More specifically the present invention is directed to a multi-dose aqueous ophthalmic composition (e.g., a solution, a suspension, an emulsion or the like) containing a 1H-indole-1-carboxamide (e.g., N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide) and use thereof for treatment of an ophthalmic disease at the back of the eye such as age related macular degeneration (AMD).

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