The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 08, 2019

Filed:

May. 07, 2015
Applicants:

Cornell University, Ithaca, NY (US);

Inserm, Paris, FR;

Inventors:

Matteo Porotto, New York, NY (US);

Anne Moscona, New York, NY (US);

Branka Horvat, Lyons, FR;

Cyrille Mathieu, Lyons, FR;

Assignees:

Cornell University, Ithaca, NY (US);

INSERM, Paris, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/65 (2017.01); A61K 31/355 (2006.01); A61K 38/16 (2006.01); A61K 47/55 (2017.01); A61K 47/64 (2017.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/16 (2006.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/42 (2017.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 47/65 (2017.08); A61K 31/355 (2013.01); A61K 38/162 (2013.01); A61K 47/551 (2017.08); A61K 47/645 (2017.08); A61K 9/127 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/16 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/42 (2013.01);
Abstract

The present application relates to an inhibitor of fusion between a viral membrane from an enveloped virus and a cell membrane, where the viral membrane comprises a fusion mediating protein including a C-terminal peptide. The inhibitor comprises the C-terminal peptide of the fusion mediating protein from an enveloped virus and tocopherol or a derivative or pharmaceutically acceptable salt thereof attached to the C-terminal peptide. Also disclosed is a pharmaceutical composition including the inhibitor as well as methods of inhibiting viral fusion, blocking viral spread, and preventing or treating viral infection, with the inhibitor or pharmaceutical composition.


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