The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2019
Filed:
Oct. 28, 2013
Vanderbilt University, Nashville, TN (US);
Craig L. Duvall, Nashville, TN (US);
Christopher E. Nelson, Nashville, TN (US);
James Kintzing, Nashville, TN (US);
Joshua M. Shannon, Nashville, TN (US);
Mukesh K. Gupta, Nashville, TN (US);
Scott A. Guelcher, Thompsons Station, TN (US);
Elizabeth J. Adolph, Nashville, TN (US);
Jeffrey M. Davidson, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.