The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2019
Filed:
Jun. 19, 2013
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
David J. Hackam, Pittsburgh, PA (US);
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEMS OF HIGHER EDUCATION, Pittsburgh, PA (US);
Abstract
The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis ('NEC') or inflammatory bowel disease ('IBD') comprising administering, to a subject in need of such treatment, an effective amount of a gap junction enhancing agent (“GJEA”), for example a peptide (“GJP”) or peptide analog (“GJPA”). It is based, at least in part, on the discovery that greater functionality of gap junctions between enterocytes increases their rate of migration and reduces the severity of intestinal inflammation.