The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2019
Filed:
Mar. 15, 2017
Applicant:
Florida A&m University, Tallahassee, FL (US);
Inventors:
Mandip Sachdeva, Tallahassee, FL (US);
Ketankumar Patel, Tallahassee, FL (US);
Arun Rishi, Detroit, MI (US);
Assignee:
Florida A&M University, Tallahassee, FL (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 47/16 (2006.01); A61K 47/44 (2017.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01);
U.S. Cl.
CPC ...
A61K 31/433 (2013.01); A61K 9/0053 (2013.01); A61K 9/1075 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 47/16 (2013.01); A61K 47/44 (2013.01);
Abstract
A solid self-micro/nano emulsifying formulation comprising CARP-1 functional mimetics (CFM; e.g., CFM-4.16 or CFM-4.17) for oral administration, and methods of fabrication and use thereof to treat cancer (e.g., breast cancer, triple negative breast cancer, resistant lung cancer, and non-resistant lung cancer) and reduce tumor volume. Solid self-micro/nano emulsifying formulation of CFM compounds was found to have significantly enhanced drug loading, aqueous solubility, and oral bioavailability of the formulation.