The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Sep. 11, 2015
Applicant:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Inventors:
David M. Sabatini, Cambridge, MA (US);
Lynne Chantranupong, Cambridge, MA (US);
Rachel L. Wolfson, Cambridge, MA (US);
Jose Orozco, Boston, MA (US);
Robert A. Saxton, Cambridge, MA (US);
Shomit Sengupta, Belmont, MA (US);
Assignee:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6872 (2013.01); G01N 33/5041 (2013.01); G01N 33/53 (2013.01); G01N 2500/02 (2013.01);
Abstract
The present invention provides methods of identifying modulators of mTORC1 based upon their effect on GATOR2-Sestrin binding or Sestrin-leucine binding; and the use of such modulators to alter mTORC1 activity in a cell and to treat disease and conditions that are effected by mTORC1 activity.