The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Sep. 04, 2014
Applicant:
Csir, Pretoria, ZA;
Inventors:
Stephanie Fanucchi, Johannesburg, ZA;
Youtaro Shibayama, Pretoria, ZA;
Shaun Burd, Pretoria, ZA;
Musa M. Mhlanga, Johannesburg, ZA;
Assignee:
CSIR, Pretoria, ZA;
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/01 (2006.01); C12N 9/22 (2006.01); C12N 15/63 (2006.01); C12Q 1/6841 (2018.01); C12Q 1/6876 (2018.01);
U.S. Cl.
CPC ...
C12N 15/01 (2013.01); C12N 9/22 (2013.01); C12N 15/63 (2013.01); C12Q 1/6841 (2013.01); C12Q 1/6876 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01);
Abstract
This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell and to methods of silencing gene expression in a cell by way of perturbing gene regulatory elements which are engaged in chromosomal contact.