The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Nov. 02, 2016
Applicant:
The University of Chicago, Chicago, IL (US);
Inventor:
Yang-Xin Fu, Chicago, IL (US);
Assignee:
The University of Chicago, Chicago, IL (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/525 (2006.01); C07K 14/625 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 38/19 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C07K 16/46 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 14/525 (2013.01); A61K 9/0019 (2013.01); A61K 38/191 (2013.01); A61K 45/06 (2013.01); A61K 47/6803 (2017.08); A61K 47/6813 (2017.08); A61K 47/6851 (2017.08); A61K 47/6855 (2017.08); A61K 47/6863 (2017.08); C07K 14/625 (2013.01); C07K 16/2863 (2013.01); C07K 16/3015 (2013.01); C07K 16/3046 (2013.01); C07K 16/32 (2013.01); C07K 16/46 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/622 (2013.01); C07K 2319/33 (2013.01);
Abstract
Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human LIGHT protein. The targeting of embodiments of LIGHT to tumor cells reduces tumor growth and reduces metastases.